burimamide

Ligand id: 1229

Name: burimamide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 7
Topological polar surface area 84.83
Molecular weight 262.13
XLogP 3.14
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
H3 receptor Antagonist Antagonist 7.1 pKi - 3,7
pKi 7.1 [3,7]
H4 receptor Antagonist Antagonist 6.7 – 7.4 pKi - 2-5,8
pKi 6.7 – 7.4 [2-5,8]
H2 receptor Agonist Full agonist 5.6 – 5.7 pEC50 - 1
pEC50 5.6 – 5.7 [1]
Selectivity at mouse GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
H4 receptor Antagonist Antagonist 6.1 pKi - 4
pKi 6.1 [4]
Selectivity at rat GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
H3 receptor Antagonist Antagonist 7.3 pKi - 7
pKi 7.3 [7]
H4 receptor Antagonist Antagonist 6.0 pKi - 4
pKi 6.0 [4]
H2 receptor Antagonist Antagonist 5.5 pKi - 6
pKi 5.5 [6]