DCG-IV

Ligand id: 1377

Name: DCG-IV

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 4
Rotatable bonds 4
Topological polar surface area 137.92
Molecular weight 203.04
XLogP -4.41
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
mGlu3 receptor Hs Agonist Full agonist 7.2 pKi - 3
pKi 7.2 [3]
mGlu2 receptor Rn Agonist Full agonist 7.0 pKi - 2,6
pKi 7.0 [2,6]
mGlu3 receptor Rn Agonist Full agonist 6.8 pKi - 6
pKi 6.8 [6]
mGlu2 receptor Hs Agonist Full agonist 6.5 pKi - 3
pKi 6.5 [3]
mGlu7 receptor Hs Antagonist Antagonist 4.7 pKi - 7
pKi 4.7 [7]
mGlu1 receptor Rn Antagonist Antagonist 4.1 pKi - 5
pKi 4.1 [5]
mGlu6 receptor Rn Antagonist Antagonist 5.6 pEC50 - 1
pEC50 5.6 [1]
mGlu8 receptor Hs Antagonist Antagonist 5.5 pIC50 - 4
pIC50 5.5 [4]
mGlu5 receptor Rn Antagonist Antagonist 4.7 pIC50 - 5
pIC50 4.7 [5]
Ligand mentioned in the following text fields