DCG-IV

Ligand id: 1377

Name: DCG-IV

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 4
Rotatable bonds 4
Topological polar surface area 137.92
Molecular weight 203.04
XLogP -4.41
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
mGlu3 receptor Agonist Full agonist 7.2 pKi - 3
pKi 7.2 [3]
mGlu2 receptor Agonist Full agonist 6.5 pKi - 3
pKi 6.5 [3]
mGlu7 receptor Antagonist Antagonist 4.7 pKi - 7
pKi 4.7 [7]
mGlu8 receptor Antagonist Antagonist 5.5 pIC50 - 4
pIC50 5.5 [4]
Selectivity at rat GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
mGlu2 receptor Agonist Full agonist 7.0 pKi - 2,6
pKi 7.0 [2,6]
mGlu3 receptor Agonist Full agonist 6.8 pKi - 6
pKi 6.8 [6]
mGlu1 receptor Antagonist Antagonist 4.1 pKi - 5
pKi 4.1 [5]
mGlu6 receptor Antagonist Antagonist 5.6 pEC50 - 1
pEC50 5.6 [1]
mGlu5 receptor Antagonist Antagonist 4.7 pIC50 - 5
pIC50 4.7 [5]
Ligand mentioned in the following text fields