3,3'-difluorobenzaldazine

Ligand id: 1424

Name: 3,3'-difluorobenzaldazine

Abbreviated name: DFB

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 24.72
Molecular weight 244.08
XLogP 6.11
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
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Target Type Action Affinity Units Concentration range (M) Reference
mGlu5 receptor Allosteric modulator Positive 5.6 – 8.5 pIC50 - 1-2
pIC50 5.6 – 8.5 [1-2]