MPEP

Ligand id: 1426

Name: MPEP

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 12.89
Molecular weight 193.09
XLogP 3.77
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Parameter Concentration range (M) Reference
mGlu4 receptor Hs Allosteric modulator Positive 6.3 – 6.6 pEC50 - 3
pEC50 6.3 – 6.6 (EC50 5.5x10-7 – 2.6x10-7 M) obtained in the presence of L-AP4 [3]
mGlu5 receptor Hs Allosteric modulator Negative 7.4 – 7.7 pIC50 - 1-2
pIC50 7.4 – 7.7 [1-2]