bufotenine

Ligand id: 144

Name: bufotenine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 39.26
Molecular weight 204.13
XLogP 1.18
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
5-HT1D receptor Hs Antagonist Antagonist 7.7 – 8.0 pKi - 3
pKi 7.7 – 8.0 [3]
5-HT6 receptor Rn Antagonist Antagonist 7.0 – 8.4 pKi - 2
pKi 7.0 – 8.4 [2]
5-HT7 receptor Mm Agonist Full agonist 7.0 pKi - 5
pKi 7.0 [5]
5-HT2A receptor Hs Antagonist Antagonist 6.8 pKi - 1
pKi 6.8 [1]
5-HT5A receptor Mm Antagonist Antagonist 5.3 – 6.0 pKi - 4,6
pKi 5.3 – 6.0 [4,6]