Ligand id: 1586

Name: levocabastine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 64.33
Molecular weight 420.22
XLogP 6.18
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
We have been unable to find affinity data for this drug (at the human target) to substantiate this MMOA.
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
NTS2 receptor Hs Agonist Full agonist 6.8 pKi - 3-4
pKi 6.8 [3-4]
NTS2 receptor Mm Agonist Full agonist 8.4 – 8.7 pIC50 - 1
pIC50 8.4 – 8.7 [1]
NTS2 receptor Rn Agonist Partial agonist 8.0 pIC50 - 2
pIC50 8.0 [2]