levocabastine

Ligand id: 1586

Name: levocabastine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 64.33
Molecular weight 420.22
XLogP 6.18
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
We have been unable to find affinity data for this drug (at the human target) to substantiate this MMOA.
Selectivity at human GPCRs
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Target Type Action Affinity Units Concentration range (M) Reference
NTS2 receptor Agonist Full agonist 6.8 pKi - 3-4
pKi 6.8 [3-4]
Selectivity at mouse GPCRs
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Target Type Action Affinity Units Concentration range (M) Reference
NTS2 receptor Agonist Full agonist 8.4 – 8.7 pIC50 - 1
pIC50 8.4 – 8.7 [1]
Selectivity at rat GPCRs
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Target Type Action Affinity Units Concentration range (M) Reference
NTS2 receptor Agonist Partial agonist 8.0 pIC50 - 2
pIC50 8.0 [2]