diprenorphine

Ligand id: 1617

Name: diprenorphine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 62.16
Molecular weight 425.26
XLogP 2.82
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
κ receptor Antagonist Antagonist 9.6 – 9.7 pKi - 1,3-5
pKi 9.6 – 9.7 [1,3-5]
δ receptor Agonist Full agonist 9.3 pKi - 3
pKi 9.3 [3]
μ receptor Antagonist Antagonist 9.1 pKi - 3
pKi 9.1 [3]
Selectivity at mouse GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
μ receptor Antagonist Antagonist 10.1 pKi - 2
pKi 10.1 [2]