naloxone

Ligand id: 1638

Name: naloxone

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 70
Molecular weight 327.15
XLogP 0.61
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
μ receptor Antagonist Antagonist 8.9 pKi - 7
pKi 8.9 [7]
κ receptor Antagonist Antagonist 7.6 – 8.6 pKi - 4,6-7,9-10
pKi 7.6 – 8.6 [4,6-7,9-10]
δ receptor Antagonist Antagonist 7.2 pKi - 7
pKi 7.2 [7]
Selectivity at mouse GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
μ receptor Antagonist Antagonist 9.0 pKi - 5
pKi 9.0 [5]
δ receptor Antagonist Antagonist 7.8 pKi - 5
pKi 7.8 [5]
κ receptor Antagonist Antagonist 8.3 pIC50 - 8
pIC50 8.3 [8]
δ receptor Antagonist Antagonist 6.2 pIC50 - 8
pIC50 6.2 [8]
Selectivity at rat GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
κ receptor Antagonist Antagonist 7.7 – 8.0 pKi - 1-3
pKi 7.7 – 8.0 [1-3]
Ligand mentioned in the following text fields