nalbuphine

Ligand id: 1663

Name: nalbuphine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 73.16
Molecular weight 357.19
XLogP 1.45
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
μ receptor Hs Agonist Agonist 8.8 pKi - 1
pKi 8.8 (Ki 1.6x10-9 M) [1]
κ receptor Hs Agonist Full agonist 7.4 – 7.5 pKi - 3
pKi 7.4 – 7.5 [3]
δ receptor Hs Agonist Agonist 6.2 pKi - 1
pKi 6.2 (Ki 5.8x10-7 M) [1]
κ receptor Mm Agonist Full agonist 7.4 pIC50 - 2
pIC50 7.4 [2]