EGIS-7625

Ligand id: 176

Name: EGIS-7625

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 75.64
Molecular weight 326.17
XLogP 3.92
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
5-HT2B receptor Antagonist Antagonist 9.0 pKi - 1
pKi 9.0 (Ki 1x10-9 M) [1]
5-HT2C receptor Antagonist Antagonist 7.7 pKi - 1
pKi 7.7 [1]
5-HT2A receptor Antagonist Antagonist 6.2 pKi - 1
pKi 6.2 [1]
Selectivity at rat GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
5-HT2A receptor Antagonist Antagonist 6.5 pKi - 1
pKi 6.5 [1]