ticagrelor

Ligand id: 1765

Name: ticagrelor

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: ticagrelor

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 10
Hydrogen bond donors 4
Rotatable bonds 10
Topological polar surface area 163.74
Molecular weight 522.19
XLogP 2.09
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
P2Y12 receptor Hs Antagonist Antagonist 8.6 pKB - 2
pKB 8.6 [2]
P2Y12 receptor Hs Antagonist Antagonist 7.8 – 8.7 pKi - 3-4
pKi 8.7 (Ki 1.99x10-9 M) [3]
Description: Binding data obtained using washed platelets in 96-well plates, with [125I]-P2Y12 antagonist as radioligand.
pKi 7.8 (Ki 1.4x10-8 M) [4]
Selectivity at transporters
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
Equilibrative nucleoside transporter 1 Hs Inhibitor Inhibition 7.3 pKi - 1
pKi 7.3 [1]
Ligand mentioned in the following text fields