PGE1

Ligand id: 1882

Name: PGE1

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 13
Topological polar surface area 94.83
Molecular weight 354.24
XLogP 3.31
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
EP4 receptor Agonist Full agonist 8.8 pKi - 3
pKi 8.8 (Ki 1.58x10-9 M) [3]
EP2 receptor Agonist Full agonist 8.0 pKi - 1
pKi 8.0 (Ki 9.1x10-9 M) [1]
DP1 receptor Agonist Full agonist 7.3 pKi - 10
pKi 7.3 [10]
EP1 receptor Agonist Full agonist 6.8 pKi - 8
pKi 6.8 [8]
IP receptor Agonist Full agonist 6.5 – 6.8 pKi - 7,9
pKi 6.5 – 6.8 (Ki 3.18x10-7 – 1.5x10-7 M) [7,9]
EP4 receptor Agonist Full agonist 9.5 pEC50 - 5
pEC50 9.5 (EC50 3.1x10-10 M) [5]
Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
CatSper1 Activator Full agonist 6.3 pEC50 - 6
pEC50 6.3 (EC50 5x10-7 M) [6]
Voltage: -80.0 mV
Description: Patch clamp electrophysiology
CatSper2 Activator Full agonist 6.3 pEC50 - 6
pEC50 6.3 (EC50 5x10-7 M) [6]
Voltage: -80.0 mV
Description: Patch clamp electrophysiology.
CatSper3 Activator Full agonist 6.3 pEC50 - 6
pEC50 6.3 (EC50 5x10-7 M) [6]
Voltage: -80.0 mV
Description: Patch clamp electrophysiology.
CatSper4 Activator Full agonist 6.3 pEC50 - 6
pEC50 6.3 (EC50 5x10-7 M) [6]
Voltage: -80.0 mV
Description: Patch clamp electrophysiology.
Selectivity at mouse GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
EP3 receptor Agonist Full agonist 9.0 pKi - 4
pKi 9.0 (Ki 1x10-9 M) [4]
EP4 receptor Agonist Full agonist 8.7 pKi - 4
pKi 8.7 [4]
EP2 receptor Agonist Full agonist 8.0 pKi - 4
pKi 8.0 [4]
IP receptor Agonist Full agonist 7.5 pKi - 4
pKi 7.5 [4]
EP1 receptor Agonist Full agonist 7.4 pKi - 4
pKi 7.4 [4]
Selectivity at rat GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
EP4 receptor Agonist Full agonist 9.2 pKi - 2
pKi 9.2 [2]
EP3 receptor Agonist Full agonist 9.0 pKi - 2
pKi 9.0 (Ki 1x10-9 M) [2]
EP2 receptor Agonist Full agonist 8.0 pKi - 2
pKi 8.0 [2]
EP1 receptor Agonist Full agonist 7.0 pKi - 2
pKi 7.0 [2]
EP3 receptor Agonist Full agonist 9.4 pEC50 - 2
pEC50 9.4 (EC50 4.5x10-10 M) EP3α isoform [2]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Ligand mentioned in the following text fields