PGE1

Ligand id: 1882

Name: PGE1

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 13
Topological polar surface area 94.83
Molecular weight 354.24
XLogP 3.31
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
EP4 receptor Rn Agonist Full agonist 9.2 pKi - 2
pKi 9.2 [2]
EP3 receptor Mm Agonist Full agonist 9.0 pKi - 4
pKi 9.0 (Ki 1x10-9 M) [4]
EP3 receptor Rn Agonist Full agonist 9.0 pKi - 2
pKi 9.0 (Ki 1x10-9 M) [2]
EP4 receptor Hs Agonist Full agonist 8.8 pKi - 3
pKi 8.8 (Ki 1.58x10-9 M) [3]
EP4 receptor Mm Agonist Full agonist 8.7 pKi - 4
pKi 8.7 [4]
EP2 receptor Hs Agonist Full agonist 8.0 pKi - 1
pKi 8.0 (Ki 9.1x10-9 M) [1]
EP2 receptor Mm Agonist Full agonist 8.0 pKi - 4
pKi 8.0 [4]
EP2 receptor Rn Agonist Full agonist 8.0 pKi - 2
pKi 8.0 [2]
IP receptor Mm Agonist Full agonist 7.5 pKi - 4
pKi 7.5 [4]
EP1 receptor Mm Agonist Full agonist 7.4 pKi - 4
pKi 7.4 [4]
DP1 receptor Hs Agonist Full agonist 7.3 pKi - 10
pKi 7.3 [10]
EP1 receptor Rn Agonist Full agonist 7.0 pKi - 2
pKi 7.0 [2]
EP1 receptor Hs Agonist Full agonist 6.8 pKi - 8
pKi 6.8 [8]
IP receptor Hs Agonist Full agonist 6.5 – 6.8 pKi - 7,9
pKi 6.5 – 6.8 (Ki 3.18x10-7 – 1.5x10-7 M) [7,9]
EP4 receptor Hs Agonist Full agonist 9.5 pEC50 - 5
pEC50 9.5 (EC50 3.1x10-10 M) [5]
EP3 receptor Rn Agonist Full agonist 9.4 pEC50 - 2
pEC50 9.4 (EC50 4.5x10-10 M) EP3α isoform [2]
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
CatSper1 Hs Activator Full agonist 6.3 pEC50 - 6
pEC50 6.3 (EC50 5x10-7 M) [6]
Voltage: -80.0 mV
Description: Patch clamp electrophysiology
CatSper2 Hs Activator Full agonist 6.3 pEC50 - 6
pEC50 6.3 (EC50 5x10-7 M) [6]
Voltage: -80.0 mV
Description: Patch clamp electrophysiology.
CatSper3 Hs Activator Full agonist 6.3 pEC50 - 6
pEC50 6.3 (EC50 5x10-7 M) [6]
Voltage: -80.0 mV
Description: Patch clamp electrophysiology.
CatSper4 Hs Activator Full agonist 6.3 pEC50 - 6
pEC50 6.3 (EC50 5x10-7 M) [6]
Voltage: -80.0 mV
Description: Patch clamp electrophysiology.
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Ligand mentioned in the following text fields