butaprost (free acid form)

Ligand id: 1892

Name: butaprost (free acid form)

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 13
Topological polar surface area 94.83
Molecular weight 394.27
XLogP 3.75
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
EP2 receptor Agonist Full agonist 5.9 – 7.0 pKi - 1,3
pKi 5.9 – 7.0 [1,3]
EP3 receptor Agonist Full agonist 5.8 pKi - 1
pKi 5.8 (Ki 1.643x10-6 M) EP3-III isoform [1]
DP1 receptor Agonist Full agonist 4.9 pKi - 1
pKi 4.9 [1]
EP4 receptor Agonist Full agonist 4.7 pKi - 1
pKi 4.7 [1]
TP receptor Agonist Full agonist 4.7 pKi - 1
pKi 4.7 [1]
IP receptor Agonist Full agonist 4.3 pKi - 1
pKi 4.3 [1]
Selectivity at rat GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
EP2 receptor Agonist Full agonist 7.2 pKi - 2
pKi 7.2 [2]
EP3 receptor Agonist Full agonist 4.9 pKi - 2
pKi 4.9 (Ki 1.18x10-5 M) EP3α isoform [2]
EP4 receptor Agonist Full agonist 4.8 pKi - 2
pKi 4.8 [2]