butaprost (free acid form)

Ligand id: 1892

Name: butaprost (free acid form)

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 13
Topological polar surface area 94.83
Molecular weight 394.27
XLogP 3.75
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
EP2 receptor Rn Agonist Full agonist 7.2 pKi - 2
pKi 7.2 [2]
EP2 receptor Hs Agonist Full agonist 5.9 – 7.0 pKi - 1,3
pKi 5.9 – 7.0 [1,3]
EP3 receptor Hs Agonist Full agonist 5.8 pKi - 1
pKi 5.8 (Ki 1.643x10-6 M) EP3-III isoform [1]
EP3 receptor Rn Agonist Full agonist 4.9 pKi - 2
pKi 4.9 (Ki 1.18x10-5 M) EP3α isoform [2]
DP1 receptor Hs Agonist Full agonist 4.9 pKi - 1
pKi 4.9 [1]
EP4 receptor Rn Agonist Full agonist 4.8 pKi - 2
pKi 4.8 [2]
EP4 receptor Hs Agonist Full agonist 4.7 pKi - 1
pKi 4.7 [1]
TP receptor Hs Agonist Full agonist 4.7 pKi - 1
pKi 4.7 [1]
IP receptor Hs Agonist Full agonist 4.3 pKi - 1
pKi 4.3 [1]