misoprostol (methyl ester)

Ligand id: 1936

Name: misoprostol (methyl ester)

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 14
Topological polar surface area 83.83
Molecular weight 382.27
XLogP 3.57
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
EP3 receptor Agonist Full agonist 6.5 pKi - 1
pKi 6.5 (Ki 3.19x10-7 M) EP3-III isoform [1]
EP4 receptor Agonist Full agonist 5.3 pKi - 1
pKi 5.3 [1]
EP2 receptor Agonist Full agonist 5.0 pKi - 1
pKi 5.0 [1]