AH23848

Ligand id: 1949

Name: AH23848

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 11
Topological polar surface area 76.07
Molecular weight 477.25
XLogP 6.7
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
TP receptor Antagonist Antagonist 6.2 pKi - 1
pKi 6.2 [1]
EP4 receptor Antagonist Antagonist 4.9 – 5.6 pKi - 1,3
pKi 4.9 – 5.6 [1,3]
pKi 5.0 [1]
Selectivity at rat GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
EP4 receptor Antagonist Antagonist 5.1 pKi - 2
pKi 5.1 [2]