amoxapine

Ligand id: 201

Name: amoxapine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 36.86
Molecular weight 313.1
XLogP 4.07
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
5-HT2A receptor Rn Antagonist Antagonist 9.0 pKi - 4
pKi 9.0 [4]
5-HT2C receptor Rn Antagonist Antagonist 8.7 pKi - 4
pKi 8.7 [4]
5-HT6 receptor Rn Antagonist Antagonist 7.5 – 8.2 pKi - 3,5
pKi 7.5 – 8.2 [3,5]
5-HT7 receptor Rn Antagonist Antagonist 7.4 pKi - 5
pKi 7.4 [5]
5-HT6 receptor Hs Antagonist Antagonist 7.3 pKi - 2
pKi 7.3 [2]
Selectivity at transporters
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
NET Hs Inhibitor Inhibition 7.9 pKi - 1
pKi 7.9 (Ki 1.3x10-8 M) [1]
SERT Hs Inhibitor Inhibition 7.7 pKi - 1
pKi 7.7 (Ki 1.8x10-8 M) [1]
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