fluphenazine

Ligand id: 204

Name: fluphenazine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 55.25
Molecular weight 437.17
XLogP 4.41
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
D2 receptor Antagonist Antagonist 8.8 pKi - 4
pKi 8.8 (Ki 1.44x10-9 M) [4]
5-HT7 receptor Antagonist Inverse agonist 7.9 pKi - 2
pKi 7.9 [2]
D5 receptor Antagonist Antagonist 7.9 pKi - 5
pKi 7.9 [5]
D1 receptor Antagonist Antagonist 7.7 pKi - 5
pKi 7.7 [5]
H1 receptor Antagonist Antagonist 7.7 pKi - 1
pKi 7.7 [1]
5-HT2A receptor Antagonist Antagonist 7.5 pKi - 1
pKi 7.5 [1]
5-HT6 receptor Antagonist Inverse agonist 7.3 – 7.4 pKi - 2
pKi 7.3 – 7.4 [2]
Selectivity at rat GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
5-HT7 receptor Antagonist Inverse agonist 8.1 pKi - 3
pKi 8.1 [3]
5-HT6 receptor Antagonist Inverse agonist 7.8 pKi - 3
pKi 7.8 [3]