melatonin

Ligand id: 224

Name: melatonin

Abbreviated name: MLT

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: melatonin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 54.12
Molecular weight 232.12
XLogP 1.34
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Natural/Endogenous Targets
Target
MT1 receptor
MT2 receptor
Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
MT2 receptor Agonist Full agonist 9.4 – 9.8 pKi - 1-3
pKi 9.4 – 9.8 [1-3]
MT1 receptor Agonist Full agonist 9.1 – 9.7 pKi - 1-3
pKi 9.1 – 9.7 [1-3]
5-HT2B receptor Antagonist Antagonist 5.2 pKi - 4
pKi 5.2 [4]
Ligand mentioned in the following text fields