PG 97-269

Ligand id: 2268

Name: PG 97-269

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
VPAC1 receptor Antagonist Antagonist 7.1 – 8.7 pIC50 - 1-2,4
pIC50 8.7 (IC50 2x10-9 M) [4]
Description: cyclic AMP formation in CHO cells stably expressing recombinant receptor
pIC50 8.7 (IC50 2x10-9 M) [2,4]
Description: inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor, or from LoVo cells which endogenously express the receptor
pIC50 8.0 (IC50 9.9x10-9 M) [1]
Description: inhibition of calcium influx stimulated by 30nM VIP in CHO cells stably expressing recombinant receptor
pIC50 7.1 (IC50 8x10-8 M) [1]
Description: inhibition of cyclic AMP formation stimulated by 0.3nM VIP in CHO cells stably expressing recombinant receptor
VPAC2 receptor Antagonist Antagonist 5.5 – 5.7 pIC50 - 2,4
pIC50 5.7 (IC50 2x10-6 M) [4]
Description: inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor
pIC50 5.5 (IC50 3x10-6 M) [2]
Description: inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
PAC1 receptor Antagonist Antagonist - - - 3
[3]
Selectivity at rat GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
VPAC1 receptor Antagonist Antagonist 8.0 pIC50 - 2
pIC50 8.0 (IC50 1x10-8 M) [2]
Description: inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
VPAC2 receptor Antagonist Antagonist 5.7 pIC50 - 2
pIC50 5.7 (IC50 2x10-6 M) [2]
Description: inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
PAC1 receptor Antagonist Antagonist 4.5 pIC50 - 2
pIC50 4.5 (IC50 3x10-5 M) [2]
Description: inhibition of [125I]-[Ac-His1]PACAP-27 binding to membranes from CHO cells stably expressing the recombinant receptor