Ligand Id: 2268
Ligand name PG 97-269


Summary Biological activity References Structure Similar ligands

Selectivity data from the Guide to Receptors and Channels (GRAC), 5th Edition.

Selectivity at human targets (unless otherwise stated)
Key to terms and symbols Click column headers to sort
Receptor Type Action Affinity Units Concentration range (M) Reference
VPAC1 receptor Antagonist Antagonist 7.1 pIC50 - 4
VPAC1 receptor Antagonist Antagonist 8.0 pIC50 - 4
VPAC1 receptor Antagonist Antagonist 8.7 pIC50 - 1
VPAC1 receptor Antagonist Antagonist 8.7 pIC50 - 2
VPAC1 receptor Antagonist Antagonist 8.7 pIC50 - 2

Selectivity data from IUPHAR-DB

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Receptor Type Action Affinity Units Concentration range (M) Reference
PAC1 receptor Antagonist Antagonist - - - 3
VPAC1 receptor Antagonist Antagonist 7.1 – 8.7 pIC50 - 1-2,4
VPAC2 receptor Antagonist Antagonist 5.5 – 5.7 pIC50 - 1-2
Selectivity at rat GPCRs
Key to terms and symbols Click column headers to sort
Receptor Type Action Affinity Units Concentration range (M) Reference
VPAC1 receptor Antagonist Antagonist 8.0 pIC50 - 1
VPAC2 receptor Antagonist Antagonist 5.7 pIC50 - 1
PAC1 receptor Antagonist Antagonist 4.5 pIC50 - 1

Please note: The activity data given on this ligand page represents selected literature values and may not include all reported data.
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