[Ala11,22,28]VIP   Click here for help

GtoPdb Ligand ID: 2278

Synonyms: [Ala11,22,28]vasoactive intestinal peptide
Click here for help
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
VPAC1 receptor Hs Agonist Agonist 8.1 pKi - 2
pKi 8.1 (Ki 7.4x10-9 M) [2]
Description: inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
VPAC2 receptor Hs Agonist Agonist 5.6 pKi - 2
pKi 5.6 (Ki 2.352x10-6 M) [2]
Description: inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
VPAC1 receptor Hs Agonist Agonist 7.6 – 10.2 pEC50 - 1-2
pEC50 10.2 (EC50 5.7x10-11 M) [1]
Description: cyclic AMP formation in CHO cells stably expressing recombinant receptor
pEC50 9.4 (EC50 4x10-10 M) [2]
Description: stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor
pEC50 7.6 (EC50 2.56x10-8 M) [1]
Description: calcium influx in CHO cells stably expressing recombinant receptor
VPAC2 receptor Hs Agonist Agonist <5.0 – 5.9 pEC50 - 1-2
pEC50 5.9 (EC50 1.222x10-6 M) [2]
Description: stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor
pEC50 <5.0 (EC50 >1x10-5 M) [1]
Description: calcium influx in CHO cells stably expressing recombinant receptor
pEC50 <5.0 (EC50 >1x10-5 M) [1]
Description: cyclic AMP formation in CHO cells stably expressing recombinant receptor
PAC1 receptor Hs Agonist Agonist <5.0 – 5.8 pEC50 - 1
pEC50 5.8 (EC50 1.582x10-6 M) [1]
Description: cyclic AMP formation in CHO cells stably expressing recombinant receptor
pEC50 <5.0 (EC50 >1x10-5 M) [1]
Description: calcium influx in CHO cells stably expressing recombinant receptor