EBIO

Ligand id: 2314

Name: EBIO

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 32.34
Molecular weight 162.08
XLogP 1.78
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
KCa2.1 Activator Agonist - - 2x10-3 4,6
Conc range: 2x10-3 M [4,6]
Voltage: -80.0 mV
KCa3.1 Activator Agonist 4.1 – 4.5 pEC50 - 4-6
pEC50 4.1 – 4.5 [4-6]
Voltage: -100.0 – -50.0 mV
KCa2.3 Activator Agonist 3.8 pEC50 - 6-7
pEC50 3.8 [6-7]
KCa2.2 Activator Agonist 3.3 pEC50 - 3,6
pEC50 3.3 [3,6]
Selectivity at rat ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
KCa2.3 Activator Agonist - - 5x10-5 2
Conc range: 5x10-5 M [2]
KCa2.2 Activator Agonist 3.0 pEC50 2x10-3 1,4
pEC50 3.0 Conc range: 2x10-3 M [1,4]