leiurotoxin I   Click here for help

GtoPdb Ligand ID: 2316

Synonyms: Leiurotoxin-1 (LeTx1) | potassium channel toxin α-KTx 5.1 | scyllatoxin (ScyTx)
Comment: From Leiurus quinquestriatus hebraeus (Yellow scorpion)
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Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
KCa2.2 Hs Channel blocker Antagonist 9.5 – 9.7 pIC50 - 2-3
pIC50 9.5 – 9.7 [2-3]
KCa2.2 Rn Channel blocker Antagonist 9.5 pIC50 - 4
pIC50 9.5 [4]
KCa2.3 Hs Channel blocker Antagonist 8.7 – 9.0 pIC50 - 3,5
pIC50 8.7 – 9.0 [3,5]
KCa2.3 Rn Channel blocker Antagonist 8.1 pIC50 - 1
pIC50 8.1 [1]
KCa2.1 Hs Channel blocker Antagonist 6.5 – 7.1 pIC50 - 3-4
pIC50 6.5 – 7.1 (IC50 3x10-7 – 8x10-8 M) [3-4]
Voltage: -120.0 – 40.0 mV