nitrendipine

Ligand id: 2334

Name: nitrendipine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 107.77
Molecular weight 360.13
XLogP 4.33
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at dog ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Cav1.2 Gating inhibitor - 9.4 pIC50 - 2
pIC50 9.4 [2]
Voltage: -80.0 – 30.0 mV
Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
KCa3.1 Channel blocker Inhibition 6.1 pKd - 5
pKd 6.1 [5]
Cav1.3 Gating inhibitor Inhibition 8.4 pIC50 - 4
pIC50 8.4 (IC50 3.59x10-9 M) [4]
Description: Recombinant Cav1.3 calcium channel complexes expressed in tsA-cells
KCa3.1 Channel blocker Inhibition 7.6 pIC50 - 3
pIC50 7.6 [3]
Cav1.4 Gating inhibitor Antagonist ~6.0 pIC50 -
pIC50 ~6.0 (IC50 ~1x10-6 M)
Voltage: -70.0 mV
Selectivity at rat ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Cav1.1 Gating inhibitor Antagonist 6.0 pIC50 - 1
pIC50 6.0 [1]
Voltage: -80.0 mV
Cav1.2 Gating inhibitor Antagonist 6.0 pIC50 - 6
pIC50 6.0 [6]
Voltage: -80.0 mV