phorbol 12-myristate 13-acetate

Ligand id: 2341

Name: phorbol 12-myristate 13-acetate

Abbreviated name: PMA

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 17
Topological polar surface area 130.36
Molecular weight 616.4
XLogP 6.51
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Kir3.4 Rn Gating inhibitor - - - 3x10-8 1
Conc range: 3x10-8 M [1]
Voltage: -80.0 mV
TRPV4 Hs Activator Agonist 7.9 pEC50 - 4
pEC50 7.9 (EC50 1.25x10-8 M) [4]
Voltage: Physiological
KNa1.1 Rn Activator Agonist 7.0 – 7.3 pEC50 - 2
pEC50 7.0 – 7.3 [2]
TRPV4 Mm Activator Agonist 5.5 pEC50 - 3
pEC50 5.5 [3]
Voltage: 0.0 mV
KNa1.2 Hs Gating inhibitor Inhibition 7.9 pIC50 - 2
pIC50 7.9 [2]
Ligand mentioned in the following text fields