quinidine

Ligand id: 2342

Name: quinidine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 45.59
Molecular weight 324.18
XLogP 2.66
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Transporters Moving this Compound Across a Lipid Membrane
Transporter EC number Reaction Reference
Organic cation transporter 3
Multidrug and toxin extrusion 17
Selectivity at ion channels
Key to terms and symbols Click on species/strain names for details Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
KNa1.2 Rn Channel blocker Inhibition - - 1x10-3 2
Conc range: 1x10-3 M [2]
KNa1.1 Hs Channel blocker Antagonist - - 1x10-4 - 3x10-4 10
Conc range: 1x10-4 - 3x10-4 M [10]
K2P18.1 N/A Channel blocker - - - 1x10-4 - 2x10-4
Conc range: 1x10-4 - 2x10-4 M
KCa5.1 Hs Channel blocker - - - < 1x10-4 15
Conc range: < 1x10-4 M [15]
K2P16.1 Hs Channel blocker - - - 1x10-4 6
Conc range: 1x10-4 M [6]
KCa5.1 Mm Channel blocker - - - 2x10-5 16,19
Conc range: 2x10-5 M [16,19]
Kv1.5 Hs Channel blocker - 5.2 pKd - 14
pKd 5.2 [14]
Kv1.7 Hs Channel blocker - 4.8 pKd - 1
pKd 4.8 [1]
Kv10.1 Hs Channel blocker - 5.8 pIC50 - 12
pIC50 5.8 [12]
Kv4.2 Rn Channel blocker - 4.9 pIC50 - 3
pIC50 4.9 [3]
Nav1.5 Rn Channel blocker Pore blocker 4.4 – 5.0 pIC50 - 8,13
pIC50 4.4 – 5.0 [8,13]
Voltage: Physiological
KNa1.1 Rn Channel blocker - 4.0 pIC50 - 2,21
pIC50 4.0 [2,21]
Kv10.2 Hs Channel blocker Pore blocker 3.8 pIC50 - 5
pIC50 3.8 [5]
Kv1.4 Rn Channel blocker - 3.7 pIC50 - 20
pIC50 3.7 [20]
K2P6.1 Rn Channel blocker - - pIC50 < 1x10-4 11
pIC50 Conc range: < 1x10-4 M [11]
K2P5.1 Hs Channel blocker - - - - 9
[9]
K2P10.1 Rn Channel blocker - - - - 7
[7]
VRAC Hs Channel blocker - - - -
Selectivity at transporters
Key to terms and symbols Click on species/strain names for details Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
Plasma membrane monoamine transporter Hs Inhibitor Inhibition 4.6 pKi - 4,18
pKi 4.6 (Ki 2.53x10-5 M) [4,18]