Synonyms: phosphatidylinositol-3,4,5-trisphosphate
Compound class:
Metabolite or derivative
Comment: There is some ambiguity in the literature and on online resources as to the exact structure and stereochemistry of this compound. Other representations include CID 24755492, and CID 53477782.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Selectivity at ion channels | ||||||||||||||||||||||||||||||||||
Key to terms and symbols | Click column headers to sort | |||||||||||||||||||||||||||||||||
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Additional information and targets (data relate to human unless otherwise stated) | ||
Description | Data | Reference |
Endogenous activators at PLCγ1 | PIP3 | 1 |
Endogenous activators at PLCγ2 | PIP3, Rac1 (RAC1, P63000), Rac2 (RAC2, P15153), Rac3 (RAC3, P60763) | 1,4-5 |
Targets where the ligand is described in the comment field | |
Target | Comment |
protein kinase N1 | PKN family members are activated by Rho, PIP3 and PDK1 [3] |
protein kinase N3 | PKN family members are activated by Rho, PIP3 and PDK1 [3] |
protein kinase N2 | PKN family members are activated by Rho, PIP3 and PDK1 [3] |
Ligand mentioned in the following text fields |
Akt (Protein kinase B, PKB) family overview |
Inositol polyphosphate phosphatases overview |
Inositol polyphosphate phosphatases comments |