ivabradine

Ligand id: 2357

Name: ivabradine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 10
Topological polar surface area 60.47
Molecular weight 468.26
XLogP 2.57
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
HCN1 Channel blocker Antagonist 5.7 pIC50 - 3
pIC50 5.7 (IC50 2.25x10-6 M) [3]
HCN3 Channel blocker Antagonist 5.7 pIC50 - 3
pIC50 5.7 (IC50 2.25x10-6 M) [3]
HCN4 Channel blocker Antagonist 5.7 pIC50 - 3
pIC50 5.7 (IC50 2.25x10-6 M) [3]
Selectivity at mouse ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
HCN1 Channel blocker Antagonist 6.0 pIC50 - 1
pIC50 6.0 [1]
Voltage: -35.0 mV
HCN2 Channel blocker Antagonist 5.6 pIC50 - 3
pIC50 5.6 (IC50 2.29x10-6 M) [3]
Ligand mentioned in the following text fields