5,7-dichlorokynurenic acid

Ligand id: 2361

Name: 5,7-dichlorokynurenic acid

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 1
Topological polar surface area 66.4
Molecular weight 256.96
XLogP 1.49
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
Glycine Receptor (All subtypes) N/A Subunit-specific Inhibition - - < 1x10-6 1
Conc range: < 1x10-6 M α2 > α1 [1]
glycine receptor α2 subunit Hs Antagonist Antagonist 3.7 pIC50 -
pIC50 3.7 (IC50 1.88x10-4 M)
GluN1 Hs Antagonist Antagonist - - -
[Binds to: glycine site]
GluN2A Hs Antagonist Antagonist - - -
[Binds to: glycine site]
GluN2B Hs Antagonist Antagonist - - -
[Binds to: glycine site]
GluN2C Hs Antagonist Antagonist - - -
[Binds to: glycine site]
GluN2D Hs Antagonist Antagonist - - -
[Binds to: glycine site]