5,7-dichlorokynurenic acid

Ligand id: 2361

Name: 5,7-dichlorokynurenic acid

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 1
Topological polar surface area 66.4
Molecular weight 256.96
XLogP 1.49
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
glycine receptor α2 subunit Antagonist Antagonist 3.7 pIC50 -
pIC50 3.7 (IC50 1.88x10-4 M)
GluN1 Antagonist Antagonist - - -
[Binds to: glycine site]
GluN2A Antagonist Antagonist - - -
[Binds to: glycine site]
GluN2B Antagonist Antagonist - - -
[Binds to: glycine site]
GluN2C Antagonist Antagonist - - -
[Binds to: glycine site]
GluN2D Antagonist Antagonist - - -
[Binds to: glycine site]
Selectivity at unknown species ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Glycine Receptor (All subtypes) Subunit-specific Inhibition - - < 1x10-6 1
Conc range: < 1x10-6 M α2 > α1 [1]