colchicine

Ligand id: 2367

Name: colchicine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 83.09
Molecular weight 399.17
XLogP 1.73
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human ion channels
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Target Type Action Affinity Units Concentration range (M) Reference
glycine receptor α2 subunit Antagonist Antagonist 4.2 pIC50 -
pIC50 4.2 (IC50 6.4x10-5 M)
glycine receptor α1 subunit Antagonist Antagonist 3.5 pIC50 -
pIC50 3.5 (IC50 3.24x10-4 M)
Selectivity at human other protein targets
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Target Type Action Affinity Units Concentration range (M) Reference
tubulin beta class I Inhibitor Inhibition 8.0 pIC50 - 1
pIC50 8.0 (IC50 1.1x10-8 M) [1]
Selectivity at unknown species ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Glycine Receptor (All subtypes) Subunit-specific Inhibition - - < 1x10-6 2
Conc range: < 1x10-6 M α2 > α1 [2]
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