colchicine

Ligand id: 2367

Name: colchicine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 83.09
Molecular weight 399.17
XLogP 1.73
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
Glycine Receptor (All subtypes) N/A Subunit-specific Inhibition - - < 1x10-6 2
Conc range: < 1x10-6 M α2 > α1 [2]
glycine receptor α2 subunit Hs Antagonist Antagonist 4.2 pIC50 -
pIC50 4.2 (IC50 6.4x10-5 M)
glycine receptor α1 subunit Hs Antagonist Antagonist 3.5 pIC50 -
pIC50 3.5 (IC50 3.24x10-4 M)
Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
tubulin beta class I Hs Inhibitor Inhibition 8.0 pIC50 - 1
pIC50 8.0 (IC50 1.1x10-8 M) [1]
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