progesterone

Ligand id: 2377

Name: progesterone

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 34.14
Molecular weight 314.22
XLogP 4.83
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Natural/Endogenous Targets
Target
Mineralocorticoid receptor
Progesterone receptor
Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
CatSper2 Activator Full agonist 8.1 pEC50 - 2,6
pEC50 8.1 (EC50 7.7x10-9 M) [2,6]
Voltage: -60.0 mV
Description: Patch clamp electrophysiology, kinetic rapid mixing fluorometry; 2-3 µM shows the saturating efficacy.
CatSper3 Activator Full agonist 8.1 pEC50 - 2,6
pEC50 8.1 (EC50 7.7x10-9 M) [2,6]
Voltage: -60.0 mV
Description: Patch clamp electrophysiology, kinetic rapid mixing fluorometry, 2-3µM shows the saturating efficacy.
CatSper4 Activator Full agonist 8.1 pEC50 - 2,6
pEC50 8.1 (EC50 7.7x10-9 M) [2,6]
Voltage: -60.0 mV
Description: Patch clamp electrophysiology, kinetic rapid mixing fluorometry, 2-3µM shows the saturating efficacy.
CatSper1 Activator Full agonist 8.0 – 8.1 pEC50 - 2,6
pEC50 8.0 – 8.1 (EC50 1x10-8 – 7.7x10-9 M) [2,6]
Voltage: -60.0 mV
Description: Patch clamp electrophysiology, kinetic rapid mixing fluorometry, 2-3 µM shows the saturating efficacy.
TRPC5 Channel blocker Inhibition 5.3 pIC50 - 3
pIC50 5.3 [3]
Selectivity at human nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Progesterone receptor Agonist Agonist 8.5 pKi - 7
pKi 8.5 (Ki 3.5x10-9 M) Affinity at human PR-A [7]
Progesterone receptor Agonist Agonist 8.8 pEC50 - 1
pEC50 8.8 (EC50 1.5x10-9 M) [1]
Mineralocorticoid receptor Agonist Agonist 11.0 pIC50 - 5
pIC50 11.0 [5]
Selectivity at unknown species ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Glycine Receptor (All subtypes) Subunit-specific Inhibition - - < 1x10-6 4
Conc range: < 1x10-6 M α2 > α1, α1β [4]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Targets where the ligand is described in the comment field
Target Comment
Ligand mentioned in the following text fields