cisapride

Ligand id: 240

Name: cisapride

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 86.05
Molecular weight 465.18
XLogP 2.79
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
5-HT4 receptor Mm Agonist Full agonist 7.5 pKi - 5
pKi 7.5 [5]
5-HT4 receptor Rn Agonist Partial agonist 6.8 – 8.0 pKi - 1,4
pKi 6.8 – 8.0 [1,4]
5-HT4 receptor Hs Agonist Partial agonist 6.4 – 7.4 pKi - 2-3,6-8,11
pKi 6.4 – 7.4 [2-3,6-8,11]
5-HT7 receptor Mm Agonist Full agonist 5.8 pKi - 9
pKi 5.8 [9]
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
Kv11.1 Hs Channel blocker - 7.4 pIC50 - 10
pIC50 7.4 (IC50 4.45x10-8 M) [10]