fampridine

Ligand id: 2416

Name: fampridine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 38.91
Molecular weight 94.05
XLogP 0.37
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
This drug is non-selective in action and blocks many of the voltage-gated potassium channels. Where we have affinity data for human channels we have tagged these as the primary drug target.
Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Kir7.1 Channel blocker Antagonist - - 1x10-3 - 1x10-2 11
Conc range: 1x10-3 - 1x10-2 M [11]
Voltage: -100.0 mV
Kv1.5 Channel blocker Pore blocker 3.6 pKd - 4
pKd 3.6 (Kd 2.7x10-4 M) [4]
Kv1.8 Channel blocker - 2.8 pIC50 - 12
pIC50 2.8 (IC50 1.58x10-3 M) [12]
Kv2.2 Channel blocker - 2.8 pIC50 - 14
pIC50 2.8 (IC50 1.5x10-3 M) [14]
Kv4.1 Channel blocker - 2.0 pIC50 - 6
pIC50 2.0 [6]
Selectivity at mouse ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
TRPV2 Channel blocker Inhibition - - 5x10-3 7
Conc range: 5x10-3 M [7]
Kv1.7 Channel blocker Pore blocker 3.8 pKd - 2
pKd 3.8 [2]
Kv3.1 Channel blocker - 4.5 pIC50 - 4
pIC50 4.5 (IC50 2.9x10-5 M) [4]
Kv1.7 Channel blocker - 3.6 pIC50 - 8
pIC50 3.6 (IC50 2.45x10-4 M) [8]
Kv4.3 Channel blocker - 2.4 pIC50 - 18
pIC50 2.4 [18]
Kv4.2 Channel blocker - 2.3 pIC50 - 3
pIC50 2.3 [3]
Kv4.1 Channel blocker - 2.0 pIC50 - 5
pIC50 2.0 [5]
Selectivity at unknown species ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Kv1.5 Channel blocker - 4.3 pIC50 - 1
pIC50 4.3 [1]
Selectivity at rat ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Kv1.2 Channel blocker Pore blocker 3.2 pKd - 4
pKd 3.2 (Kd 5.9x10-4 M) [4]
Kv3.2 Channel blocker - 4.6 pIC50 - 13
pIC50 4.6 (IC50 2.4x10-5 M) [13]
Kv2.1 Channel blocker Pore blocker 3.3 pIC50 - 9
pIC50 3.3 (IC50 5x10-4 M) [9]
Kv3.3 Channel blocker - 2.9 pIC50 - 17
pIC50 2.9 [17]
Kv1.4 Channel blocker - 1.9 pIC50 - 16
pIC50 1.9 (IC50 1.25x10-2 M) [16]
Ligand mentioned in the following text fields