Δ9-tetrahydrocannabinol

Ligand id: 2424

Name: Δ9-tetrahydrocannabinol

Abbreviated name: THC

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View more information in the IUPHAR Pharmacology Education Project: delta-9-tetrahydrocannabinol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 0
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 29.46
Molecular weight 314.22
XLogP 6.21
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
CB1 receptor Hs Agonist Partial agonist 7.3 – 7.4 pKi - 4,10
pKi 7.3 – 7.4 [4,10]
CB2 receptor Hs Agonist Partial agonist 7.1 – 7.5 pKi - 2,4,8,10
pKi 7.1 – 7.5 [2,4,8,10]
GPR55 Hs Agonist Agonist 8.1 pEC50 - 9
pEC50 8.1 (EC50 8x10-9 M) [9]
GPR18 Hs Agonist Full agonist 6.0 pEC50 - 1,6
pEC50 6.0 (EC50 9.6x10-7 M) [1,6]
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
glycine receptor α2 subunit Hs Allosteric modulator Potentiation ~6.0 pEC50 -
pEC50 ~6.0 (EC50 ~1x10-6 M) ~230% potentiation
glycine receptor α1 subunit Hs Allosteric modulator Potentiation ~5.5 pEC50 -
pEC50 ~5.5 (EC50 ~3x10-6 M) ~1500% potentiation
glycine receptor α3 subunit Hs Allosteric modulator Potentiation ~5.3 pEC50 -
pEC50 ~5.3 (EC50 ~5x10-6 M) ~1500% potentiation
TRPA1 Hs Activator Agonist 4.9 pEC50 - 5
pEC50 4.9 (EC50 1.259x10-5 M) non-covalent [5]
Voltage: -60.0 mV
TRPV2 Rn Activator Activation 4.8 pEC50 - 7
pEC50 4.8 (EC50 1.4x10-5 M) [7]
TRPM8 Hs Channel blocker - - - -
Targets where the ligand is described in the comment field
Target Comment
Ligand mentioned in the following text fields