Δ9-tetrahydrocannabinol

Ligand id: 2424

Name: Δ9-tetrahydrocannabinol

Abbreviated name: THC

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View more information in the IUPHAR Pharmacology Education Project: delta-9-tetrahydrocannabinol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 0
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 29.46
Molecular weight 314.22
XLogP 6.21
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
CB1 receptor Agonist Partial agonist 7.3 – 7.4 pKi - 4,10
pKi 7.3 – 7.4 [4,10]
CB2 receptor Agonist Partial agonist 7.1 – 7.5 pKi - 2,4,8,10
pKi 7.1 – 7.5 [2,4,8,10]
GPR55 Agonist Agonist 8.1 pEC50 - 9
pEC50 8.1 (EC50 8x10-9 M) [9]
GPR18 Agonist Full agonist 6.0 pEC50 - 1,6
pEC50 6.0 (EC50 9.6x10-7 M) [1,6]
Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
glycine receptor α2 subunit Allosteric modulator Potentiation ~6.0 pEC50 -
pEC50 ~6.0 (EC50 ~1x10-6 M) ~230% potentiation
glycine receptor α1 subunit Allosteric modulator Potentiation ~5.5 pEC50 -
pEC50 ~5.5 (EC50 ~3x10-6 M) ~1500% potentiation
glycine receptor α3 subunit Allosteric modulator Potentiation ~5.3 pEC50 -
pEC50 ~5.3 (EC50 ~5x10-6 M) ~1500% potentiation
TRPA1 Activator Agonist 4.9 pEC50 - 5
pEC50 4.9 (EC50 1.259x10-5 M) non-covalent [5]
Voltage: -60.0 mV
TRPM8 Channel blocker - - - -
Selectivity at rat ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
TRPV2 Activator Activation 4.8 pEC50 - 7
pEC50 4.8 (EC50 1.4x10-5 M) [7]
Targets where the ligand is described in the comment field
Target Comment
Ligand mentioned in the following text fields