2-APB

Ligand id: 2433

Name: 2-APB

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 35.25
Molecular weight 225.13
XLogP 4.46
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
TRPM3 Gating inhibitor Antagonist - - 1x10-4 13
Conc range: 1x10-4 M [13]
Voltage: Physiological
TRPM6 Activator Agonist 3.4 – 3.7 pEC50 - 4
pEC50 3.4 – 3.7 (EC50 3.8x10-4 – 2.05x10-4 M) Potentiation [4]
Voltage: -120.0 – 100.0 mV
TRPM2 Channel blocker Antagonist 6.1 pIC50 - 12
pIC50 6.1 (IC50 8.2x10-7 M) [12]
Voltage: -60.0 mV
TRPC3 Channel blocker Antagonist 5.0 pIC50 - 5
pIC50 5.0 (IC50 1x10-5 M) [5]
Voltage: Physiological
TRPC5 Channel blocker Antagonist 4.7 pIC50 - 13
pIC50 4.7 (IC50 2x10-5 M) [13]
Voltage: -80.0 mV
TRPC1 Channel blocker Antagonist - - - 11
[11]
Voltage: -70.0 mV
TRPC4 Channel blocker - - - -
TRPC6 Channel blocker - - - -
TRPC7 Channel blocker - - - -
TRPV1 Channel blocker - - - -
TRPV6 Activator Potentiation - - -
Selectivity at mouse ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
TRPM7 Activator Activation - - > 1x10-3 7
Conc range: > 1x10-3 M [7]
TRPC2 Channel blocker Antagonist - - 5x10-5 6
Conc range: 5x10-5 M [6]
Voltage: -70.0 – 80.0 mV
TRPV3 Activator Full agonist 4.6 pEC50 - 1
pEC50 4.6 (EC50 2.51x10-5 M) [1]
Voltage: -80.0 – 80.0 mV
Description: Patch clamp electrophysiology
TRPV2 Activator Agonist 3.8 – 3.9 pEC50 - 2-3
pEC50 3.8 – 3.9 (EC50 1.6x10-4 – 1.29x10-4 M) [2-3]
Voltage: Physiological
TRPV1 Activator Agonist 3.7 – 3.9 pEC50 - 2
pEC50 3.7 – 3.9 [2]
Voltage: -40.0 mV
TRPM8 Channel blocker Antagonist 4.9 – 5.1 pIC50 - 2,8
pIC50 4.9 – 5.1 [2,8]
Voltage: 100.0 – -100.0 mV
TRPM7 Channel blocker Inhibition 3.8 pIC50 - 4
pIC50 3.8 (IC50 1.78x10-4 M) Reversible inhibition [4]
Voltage: -100.0 – 100.0 mV
Selectivity at rat ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
TRPV2 Activator - 5.0 pEC50 - 9-10
pEC50 5.0 (EC50 1x10-5 M) [9-10]
Targets where the ligand is described in the comment field
Target Comment
Ligand mentioned in the following text fields