resiniferatoxin

Ligand id: 2491

Name: resiniferatoxin

Abbreviated name: RTX

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 120.75
Molecular weight 628.27
XLogP 2.85
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Kv1.5 Hs Channel blocker - 4.6 pKd - 3
pKd 4.6 [3]
Kv1.2 Rn Channel blocker Pore blocker 4.5 pKd - 3
pKd 4.5 (Kd 3.1x10-5 M) [3]
TRPV1 Mm Activator Agonist 9.8 pEC50 - 2
pEC50 9.8 [2]
Voltage: Physiological
TRPV1 Hs Activator Agonist 8.4 pEC50 - 6
pEC50 8.4 (EC50 3.98x10-9 M) [6]
Voltage: Physiological
TRPV1 Rn Activator Agonist 7.5 pEC50 - 1
pEC50 7.5 [1]
Voltage: -40.0 mV
Kv1.1 Mm Channel blocker - 5.1 pIC50 - 3
pIC50 5.1 [3]
Kv1.7 Mm Channel blocker - 4.7 pIC50 - 5
pIC50 4.7 [5]
Kv3.1 Mm Channel blocker - 4.3 pIC50 - 3
pIC50 4.3 [3]