Ligand Id: 2514
Ligand name nifedipine

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 107.77
Molecular weight 346.12
XLogP 3.91
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Summary Biological activity References Structure Similar ligands

Selectivity data from the Guide to Receptors and Channels (GRAC), 5th Edition.

Selectivity at human targets (unless otherwise stated)
Key to terms and symbols Click column headers to sort
Receptor Type Action Affinity Units Concentration range (M) Reference
α1 Antagonist Antagonist 5.5 pIC50 -
α3 Antagonist Antagonist 4.5 pIC50 -
β (when co-expressed with the α1 subunit) Antagonist Antagonist 5.9 pIC50 -
β (when co-expressed with the α3 subunit) Antagonist Antagonist 4.9 pIC50 -
Cav1.1 Channel blocker - - - -
Cav1.2 Channel blocker - - - -
TRPM3 Activator - - - -
Receptors where the ligand is described in the comment field
Receptor Comment
Cav1.2 nifedipine, diltiazem, verapamil and calciseptine are examples of dihydropyridine antagonists
Cav1.1 nifedipine, diltiazem, verapamil and calciseptine are examples of dihydropyridine antagonists

Selectivity data from IUPHAR-DB

Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Receptor Type Action Affinity Units Concentration range (M) Reference
Kv1.5 Pore Blocker None 4.1 pKd - 5
Cav1.2 Gating inhibitor Antagonist 7.0 – 8.0 pIC50 - 2
Cav1.4 Gating inhibitor None 6.0 pIC50 - 4
Selectivity at human nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Receptor Type Action Affinity Units Concentration range (M) Reference
Pregnane X receptor Agonist Agonist - - - 7
Selectivity at mouse ion channels
Key to terms and symbols Click column headers to sort
Receptor Type Action Affinity Units Concentration range (M) Reference
Kv1.1 Pore Blocker None 4.0 pKd - 5
Kv1.7 Pore Blocker None 4.9 pIC50 - 6
Kv3.1 Pore Blocker None 3.9 pIC50 - 5
Selectivity at rat ion channels
Key to terms and symbols Click column headers to sort
Receptor Type Action Affinity Units Concentration range (M) Reference
Cav1.2 Gating inhibitor Antagonist 7.66 pIC50 - 3
Cav1.1 Gating inhibitor Antagonist 6.3 pIC50 1x10-7 - 1x10-4 1

Please note: The activity data given on this ligand page represents selected literature values and may not include all reported data.
For more details please contact: curators@iuphar-db.org