nifedipine

Ligand id: 2514

Name: nifedipine

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: nifedipine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 107.77
Molecular weight 346.12
XLogP 3.91
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Kv1.5 Channel blocker - 4.1 pKd - 2
pKd 4.1 [2]
Cav1.3 Gating inhibitor Antagonist 7.7 pIC50 - 7
pIC50 7.7 (IC50 2.01x10-8 M) [7]
Description: Recombinant Cav1.3 calcium channel complexes expressed in tsA-cells
Cav1.4 Gating inhibitor Antagonist 6.0 pIC50 - 5
pIC50 6.0 [5]
Voltage: -100.0 mV
glycine receptor α1 subunit Antagonist Antagonist 5.5 pIC50 -
pIC50 5.5 (IC50 3.3x10-6 M)
glycine receptor β subunit Antagonist Antagonist 4.9 – 5.9 pIC50 -
pIC50 5.9 (IC50 1.2x10-6 M) when co-expressed with the α1 subunit
pIC50 4.9 (IC50 1.14x10-5 M) when co-expressed with the α3 subunit
glycine receptor α3 subunit Antagonist Antagonist 4.5 pIC50 -
pIC50 4.5 (IC50 2.92x10-5 M)
TRPM3 Activator - - - -
Selectivity at human nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Pregnane X receptor Agonist Agonist - - - 1
[1]
Selectivity at mouse ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Kv1.7 Channel blocker - 4.9 pIC50 - 3
pIC50 4.9 [3]
Kv1.1 Channel blocker - 4.0 pIC50 - 2
pIC50 4.0 [2]
Kv3.1 Channel blocker - 3.9 pIC50 - 2
pIC50 3.9 [2]
Selectivity at rat ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Kv1.2 Channel blocker Pore blocker 4.7 pKd - 2
pKd 4.7 (Kd 1.8x10-5 M) [2]
Cav1.2 Gating inhibitor Antagonist 7.7 pIC50 - 6
pIC50 7.7 [6]
Voltage: -80.0 mV
Cav1.1 Gating inhibitor Antagonist 6.3 pIC50 1x10-7 - 1x10-4 4
pIC50 6.3 Conc range: 1x10-7 - 1x10-4 M [4]
Voltage: -90.0 mV