mibefradil

Ligand id: 2522

Name: mibefradil

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 12
Topological polar surface area 67.45
Molecular weight 495.29
XLogP 6.43
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
Cav3.2 Hs Channel blocker Antagonist 5.9 – 7.2 pIC50 - 2
pIC50 5.9 – 7.2 (IC50 1.1x10-6 – 6.9x10-8 M) [2]
Voltage: -110.0 – -80.0 mV
Cav2.1 Rn Gating inhibitor - 6.5 pIC50 - 1
pIC50 6.5 [1]
Voltage: -100.0 mV
Cav2.3 Rn Gating inhibitor - 6.4 pIC50 - 1
pIC50 6.4 [1]
Voltage: -100.0 mV
Cav3.1 Hs Channel blocker Antagonist 6.0 – 6.6 pIC50 - 2
pIC50 6.0 – 6.6 (IC50 1x10-6 – 2.7x10-7 M) [2]
Voltage: -110.0 – -100.0 mV
Cav3.3 Hs Channel blocker Antagonist 5.8 pIC50 - 2
pIC50 5.8 (IC50 1.5x10-6 M) [2]
Voltage: -110.0 mV
Cav1.2 Hs Channel blocker Antagonist 4.9 pIC50 - 2
pIC50 4.9 [2]
Voltage: -110.0 mV
CatSper1 Hs Channel blocker Inhibition 4.4 – 4.5 pIC50 - 3
pIC50 4.4 – 4.5 (IC50 4x10-5 – 3x10-5 M) [3]
Description: Patch clamp electrophysiology, kinetic rapid mixing fluometry
CatSper2 Hs Channel blocker Inhibition 4.4 – 4.5 pIC50 - 3
pIC50 4.4 – 4.5 (IC50 4x10-5 – 3x10-5 M) [3]
Description: Patch clamp electrophysiology and kinetic rapid mixing fluometry.
CatSper3 Hs Channel blocker Inhibition 4.4 – 4.5 pIC50 - 3
pIC50 4.4 – 4.5 (IC50 4x10-5 – 3x10-5 M) [3]
Description: Patch clamp electrophysiology, kinetic rapid mixing fluometry.
CatSper4 Hs Channel blocker Inhibition 4.4 – 4.5 pIC50 - 3
pIC50 4.4 – 4.5 (IC50 4x10-5 – 3x10-5 M) [3]
Description: Patch clamp electrophysiology, kinetic rapid mixing fluometry.
CaCC Hs Channel blocker - - - -
VRAC Hs Channel blocker - - - -