flecainide

Ligand id: 2560

Name: flecainide

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 59.59
Molecular weight 414.14
XLogP 4.3
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Kv1.7 Channel blocker - 5.1 pKd - 1
pKd 5.1 [1]
Kv1.5 Channel blocker - 4.0 pKd - 2
pKd 4.0 [2]
Selectivity at mouse ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Kv1.1 Channel blocker - 3.7 pKd - 2
pKd 3.7 [2]
Kv3.1 Channel blocker - 4.0 pIC50 - 2
pIC50 4.0 [2]
Selectivity at rat ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Kv1.2 Channel blocker Pore blocker 3.7 pKd - 2
pKd 3.7 (Kd 2.17x10-4 M) [2]