Ligand Id: 2617
Ligand name aconitine

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 12
Hydrogen bond donors 3
Rotatable bonds 11
Topological polar surface area 153.45
Molecular weight 645.31
XLogP 1.52
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

Summary Biological activity References Structure Similar ligands

Selectivity data from IUPHAR-DB

Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Receptor Type Action Affinity Units Concentration range (M) Reference
Nav1.5 Activator Agonist - - 3x10-5 - 1x10-4 2-3
Selectivity at rat ion channels
Key to terms and symbols Click column headers to sort
Receptor Type Action Affinity Units Concentration range (M) Reference
Nav1.2 Activator Agonist 5.9 pKd - 1

Please note: The activity data given on this ligand page represents selected literature values and may not include all reported data.
For more details please contact: curators@iuphar-db.org