μ-conotoxin GIIIA   Click here for help

GtoPdb Ligand ID: 2630

Synonyms: Geographutoxin I | GTx-I | Myotoxin I
Comment: From Conus geographus (Geography cone)
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Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Nav1.4 Rn Channel blocker Antagonist 7.3 – 7.7 pIC50 - 2-3
pIC50 7.3 – 7.7 [2-3]
Voltage: -120.0 – -100.0 mV
Nav1.4 Hs Channel blocker Pore blocker 5.9 pIC50 - 1
pIC50 5.9 (IC50 1.2x10-6 M) [1]
Voltage: -100.0 mV