T4

Ligand id: 2635

Name: T4

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 92.78
Molecular weight 776.69
XLogP 2.85
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Natural/Endogenous Targets
Target
Thyroid hormone receptor-α
Thyroid hormone receptor-β
Enzymes Catalysing Reactions with this Compound as a Substrate or Product
Enzyme EC number Reaction Reference
iodothyronine deiodinase 1
iodothyronine deiodinase 2
iodothyronine deiodinase 3
Transporters Moving this Compound Across a Lipid Membrane
Transporter EC number Reaction Reference
Sodium/bile acid and sulphated solute cotransporter 1
Monocarboxylate transporter 8 1
OATP2B1
Selectivity at human nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Thyroid hormone receptor-β Agonist Agonist 8.5 pIC50 - 2
pIC50 8.5 [2]
Thyroid hormone receptor-α Agonist Agonist - pIC50 - 2
pIC50 [2]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Ligand mentioned in the following text fields