tamibarotene

Ligand id: 2648

Name: tamibarotene

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 66.4
Molecular weight 351.18
XLogP 7.28
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Tamibarotene (AM 80) induces differentiation and apoptosis of HL-60 cells in vitro. It exhibits antiproliferative effects against a variety of human tumor cells lines and displays anticancer activity against acute promyelocytic leukemia in vivo
Selectivity at human nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Retinoic acid receptor-α Agonist Agonist 7.3 pEC50 - 5
pEC50 7.3 (EC50 4.5x10-8 M) [5]
Retinoic acid receptor-β Agonist Agonist 6.6 pEC50 - 5
pEC50 6.6 (EC50 2.35x10-7 M) [5]
Retinoic acid receptor-γ Agonist Agonist 6.2 pEC50 - 5
pEC50 6.2 (EC50 5.91x10-7 M) [5]
Retinoic acid receptor-α Agonist Agonist 6.9 pIC50 - 1-2,4
pIC50 6.9 [1-2,4]