dexamethasone

Ligand id: 2768

Name: dexamethasone

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: dexamethasone

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 94.83
Molecular weight 392.2
XLogP 1.14
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Mineralocorticoid receptor Agonist Agonist 9.0 pIC50 - 1,4
pIC50 9.0 [1,4]
Glucocorticoid receptor Agonist Agonist 8.1 – 9.0 pIC50 - 1,3-4
pIC50 8.1 – 9.0 [1,3-4]
Selectivity at mouse nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Pregnane X receptor Agonist Agonist 6.1 pEC50 - 2
pEC50 6.1 [2]