cyproheptadine

Ligand id: 277

Name: cyproheptadine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 3.24
Molecular weight 287.17
XLogP 7.96
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
H1 receptor Antagonist Antagonist 10.2 pKi - 3
pKi 10.2 [3]
α1B-adrenoceptor Antagonist Antagonist 7.6 pKi - 7
pKi 7.6 [7]
α1A-adrenoceptor Antagonist Antagonist 7.4 pKi - 7
pKi 7.4 [7]
5-HT7 receptor Antagonist Antagonist 6.9 pKi - 1
pKi 6.9 [1]
α1D-adrenoceptor Antagonist Antagonist 6.9 pKi - 7
pKi 6.9 [7]
5-HT6 receptor Antagonist Antagonist 6.8 pKi - 2
pKi 6.8 [2]
Selectivity at rat GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
5-HT7 receptor Antagonist Antagonist 7.1 – 7.5 pKi - 5-6
pKi 7.1 – 7.5 [5-6]
5-HT6 receptor Antagonist Antagonist 6.9 pKi - 4
pKi 6.9 [4]