cyproheptadine

Ligand id: 277

Name: cyproheptadine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 3.24
Molecular weight 287.17
XLogP 7.96
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
H1 receptor Hs Antagonist Antagonist 10.2 pKi - 3
pKi 10.2 [3]
α1B-adrenoceptor Hs Antagonist Antagonist 7.6 pKi - 7
pKi 7.6 [7]
α1A-adrenoceptor Hs Antagonist Antagonist 7.4 pKi - 7
pKi 7.4 [7]
5-HT7 receptor Rn Antagonist Antagonist 7.1 – 7.5 pKi - 5-6
pKi 7.1 – 7.5 [5-6]
5-HT6 receptor Rn Antagonist Antagonist 6.9 pKi - 4
pKi 6.9 [4]
5-HT7 receptor Hs Antagonist Antagonist 6.9 pKi - 1
pKi 6.9 [1]
α1D-adrenoceptor Hs Antagonist Antagonist 6.9 pKi - 7
pKi 6.9 [7]
5-HT6 receptor Hs Antagonist Antagonist 6.8 pKi - 2
pKi 6.8 [2]