raloxifene

Ligand id: 2820

Name: raloxifene

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 98.24
Molecular weight 473.17
XLogP 5.08
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
GPER Agonist Full agonist 7.0 pKi - 3
pKi 7.0 [3]
Selectivity at human nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Estrogen receptor-α Agonist Agonist 9.5 pKi - 4
pKi 9.5 [4]
Estrogen receptor-α Antagonist Antagonist 9.5 pKi - 2
pKi 9.5 [2]
Estrogen receptor-β Antagonist Antagonist 8.0 pKi - 1
pKi 8.0 (Ki 1x10-8 M) [1]
Ligand mentioned in the following text fields