Ligand id: 2866

Name: prednisolone

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 94.83
Molecular weight 360.19
XLogP 1.02
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
Mineralocorticoid receptor Hs Agonist Agonist 7.4 pKi - 1
pKi 7.4 (Ki 3.7x10-8 M) [1]
Glucocorticoid receptor Hs Agonist Full agonist 7.8 – 8.1 pIC50 - 2-3
pIC50 8.1 (IC50 7x10-9 M) [3]
Description: Binding to human GR in vitro.
pIC50 7.8 [2]
Mineralocorticoid receptor Hs Agonist Agonist 8.0 pIC50 - 3
pIC50 8.0 (IC50 1.1x10-8 M) [3]