Ligand id: 2868

Name: cortisol

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 94.83
Molecular weight 362.21
XLogP 0.55
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Natural/Endogenous Targets
Glucocorticoid receptor
Mineralocorticoid receptor
Selectivity at nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
Mineralocorticoid receptor Hs Agonist Agonist 9.8 – 9.9 pIC50 - 1,3
pIC50 9.8 – 9.9 [1,3]
Glucocorticoid receptor Hs Agonist Agonist 7.3 – 8.0 pIC50 - 1-3
pIC50 7.3 – 8.0 [1-3]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Targets where the ligand is described in the comment field
Target Comment
Ligand mentioned in the following text fields