AM966

Ligand id: 2905

Name: AM966

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 101.66
Molecular weight 490.13
XLogP 8.76
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
LPA1 receptor Mm Antagonist Antagonist 7.7 pEC50 - 2
pEC50 7.7 [2]
LPA1 receptor Hs Antagonist Antagonist 6.7 – 7.8 pIC50 - 1
pIC50 6.7 – 7.8 (IC50 1.99x10-7 – 1.58x10-8 M) [1]
LPA3 receptor Mm Antagonist Antagonist 6.8 pIC50 - 2
pIC50 6.8 [2]
LPA2 receptor Hs Antagonist Antagonist 5.8 pIC50 - 2
pIC50 5.8 [2]
LPA3 receptor Hs Antagonist Antagonist 5.7 pIC50 - 2
pIC50 5.7 [2]
LPA4 receptor Hs Antagonist Antagonist 5.1 pIC50 - 2
pIC50 5.1 [2]
LPA2 receptor Mm Antagonist Antagonist 4.6 pIC50 - 2
pIC50 4.6 [2]