compound 29f [PMID: 17560788]

Ligand id: 2959

Name: compound 29f [PMID: 17560788]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 3
Rotatable bonds 14
Topological polar surface area 154.75
Molecular weight 538.21
XLogP 2.83
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at rat enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
hydroxymethylglutaryl-CoA reductase Inhibitor Inhibition 9.1 pIC50 - 1
pIC50 9.1 (IC50 8.5x10-10 M) [1]
Description: Inhibition of HMG-CoA reductase
Conditions: assessed by measuring cholesterol synthesis after 30 mins