muscarinic toxin 7   Click here for help

GtoPdb Ligand ID: 314

Synonyms: m1-toxin 1 | MT7 | recombinant mamba venom toxin | rMT7 [3]
Comment: Recombinant MT7 (rMT7) is often used for bioassays due to the limited availability of the M1 muscarinic receptor-selective mamba toxin MT7 [1] or m1-toxin 1 (rMT7 has comparable affinity for M1 [3])
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Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
M1 receptor Hs Allosteric modulator Negative 11.0 – 11.1 pKi - 2-4
pKi 11.0 – 11.1 [2-4]
M2 receptor Hs Antagonist Antagonist <5.0 pKi - 3
pKi <5.0 [3]
M3 receptor Hs Antagonist Antagonist <5.0 pKi - 3
pKi <5.0 [3]
M4 receptor Hs Antagonist Antagonist <5.0 pKi - 3
pKi <5.0 [3]
M5 receptor Hs Antagonist Antagonist <5.0 pKi - 3
pKi <5.0 [3]